{"id":5836,"date":"2026-07-23T09:00:00","date_gmt":"2026-07-23T09:00:00","guid":{"rendered":"https:\/\/drcemipek.com\/peyronies-disease-treatment\/"},"modified":"2026-07-29T21:50:07","modified_gmt":"2026-07-29T21:50:07","slug":"peyronies-disease-treatment","status":"publish","type":"post","link":"https:\/\/drcemipek.com\/de\/peyronies-disease-treatment\/","title":{"rendered":"Peyronie&#8217;s Disease Treatment: Does Penile Curvature Fix Itself? When Surgery Is Needed"},"content":{"rendered":"<p><!--\n================================================================\nARTICLE 18\/20 \u2014 drcemipek.com English blog (medical tourism)\nTitle: Peyronie's Disease Treatment: Does Penile Curvature Fix Itself? When Surgery Is Needed\nAuthor: Op. Dr. Cem \u0130pek, MD  |  Reviewed: 2026-07-29\nSlug:   \/peyronies-disease-treatment\/\nWord count: ~2,350  |  Reading time: 11 min\n\nELEMENTOR PASTE INSTRUCTIONS\n1. Add \"HTML\" widget on the blank post canvas\n2. Paste EVERYTHING below (including the \n\n<style> block and JSON-LD)\n3. Do NOT wrap it in additional containers\n4. Featured image is handled outside this widget (via WP)\n5. Set Yoast SEO title \/ meta from the frontmatter block at the top\n6. Set post URL slug to: peyronies-disease-treatment\n7. Set post language to English\n================================================================\nYOAST META (copy into Yoast panel)\nTitle:        Peyronie's Disease Treatment: Curvature, Xiaflex & Surgery | Dr. Cem \u0130pek\nMeta desc:    Peyronie's disease rarely resolves on its own. A urologist explains phases, Xiaflex, traction, verapamil, plication, and grafting \u2014 and when surgery is the only durable fix.\nFocus KW:     Peyronie's disease treatment\nOG image:     \/uploads\/2026\/07\/peyronies-disease-treatment-og.jpg (1200\u00d7630)\n================================================================\n--><\/p>\n<style>\n\/* All rules are scoped to .dci-article to avoid Elementor \/ theme conflicts *\/\n.dci-article{font-family:-apple-system,BlinkMacSystemFont,\"Segoe UI\",Roboto,Helvetica,Arial,sans-serif;color:#1f2933;line-height:1.7;font-size:17px;max-width:820px;margin:0 auto}\n.dci-article *{box-sizing:border-box}\n.dci-article h1{font-size:2.15rem;line-height:1.25;font-weight:700;color:#0b2545;margin:0 0 .6em}\n.dci-article h2{font-size:1.55rem;line-height:1.3;font-weight:700;color:#0b2545;margin:2em 0 .55em;border-left:4px solid #1e7c8a;padding-left:.7em}\n.dci-article h3{font-size:1.2rem;line-height:1.35;font-weight:600;color:#123152;margin:1.6em 0 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.dci-author-text p{margin:0 0 .3em;font-size:.95rem}\n.dci-article .dci-author-text .dci-author-name{font-weight:700;color:#0b2545;font-size:1.05rem}\n.dci-article .dci-refs{font-size:.9rem;color:#4b5563;background:#f7f9fb;border-radius:6px;padding:1em 1.2em;margin:1.5em 0}\n.dci-article .dci-refs ol{margin:.3em 0 0 1.2em}\n.dci-article .dci-refs li{margin:.25em 0}\n.dci-article .dci-toc{background:#f7f9fb;border:1px solid #d9e2ec;border-radius:8px;padding:1.1em 1.4em;margin:1.5em 0 2em}\n.dci-article .dci-toc-title{font-size:.85rem;letter-spacing:.05em;text-transform:uppercase;color:#1e7c8a;font-weight:700;margin:0 0 .7em;display:flex;align-items:center;gap:.5em}\n.dci-article .dci-toc-title::before{content:\"\";display:inline-block;width:18px;height:2px;background:#1e7c8a}\n.dci-article .dci-toc ol{margin:0;padding:0;list-style:none;counter-reset:toc}\n.dci-article .dci-toc li{counter-increment:toc;margin:.35em 0;padding-left:2em;position:relative;font-size:.98rem}\n.dci-article .dci-toc li::before{content:counter(toc,decimal-leading-zero);position:absolute;left:0;top:0;color:#1e7c8a;font-weight:700;font-size:.85rem;font-variant-numeric:tabular-nums}\n.dci-article .dci-toc a{color:#0b2545;text-decoration:none;border-bottom:1px dashed transparent;transition:border-color .15s}\n.dci-article .dci-toc a:hover{border-bottom-color:#1e7c8a;color:#1e7c8a}\n@media (max-width:640px){.dci-article{font-size:16px}.dci-article h1{font-size:1.7rem}.dci-article h2{font-size:1.3rem}.dci-article table{font-size:.9rem}.dci-article .dci-author{flex-direction:column;align-items:center;text-align:center}}\n<\/style>\n<article class=\"dci-article\" itemscope itemtype=\"https:\/\/schema.org\/MedicalWebPage\">\n<h1 itemprop=\"headline\">Peyronie&#8217;s Disease Treatment: Does Penile Curvature Fix Itself? When Surgery Is Needed<\/h1>\n<div class=\"dci-meta\">\n  <span><strong itemprop=\"author\" itemscope itemtype=\"https:\/\/schema.org\/Physician\"><span itemprop=\"name\">Op. Dr. Cem \u0130pek, MD<\/span><\/strong> \u2014 Board-Certified Urologist &amp; Andrologist<\/span><br \/>\n  <span>Medically reviewed <time itemprop=\"lastReviewed\" datetime=\"2026-07-29\">29 July 2026<\/time><\/span><br \/>\n  <span>11 min read<\/span>\n<\/div>\n<div class=\"dci-answer\">\n<strong>Short answer<\/strong><br \/>\nPeyronie&#8217;s disease very rarely resolves on its own \u2014 only around 12\u201313% of untreated men see spontaneous improvement, while roughly half progress. Early (acute) disease may respond to oral therapy, traction devices, and intralesional injections such as verapamil or collagenase (Xiaflex, US only). Once curvature is stable for more than 12 months and exceeds 30 degrees or prevents intercourse, surgery \u2014 plication, plaque incision with grafting, or a penile prosthesis \u2014 is the only durable fix.\n<\/div>\n<p>Waking up to a bent, painful erection is a shock. For many men, Peyronie&#8217;s disease starts silently: a small lump under the skin of the shaft, an ache during erection, then a curvature that appears and worsens over weeks. Some hope it will fade on its own. It almost never does.<\/p>\n<p>Peyronie&#8217;s disease affects roughly <strong>3\u20139% of adult men<\/strong>, with real prevalence probably higher because most men are too embarrassed to seek help until sex becomes impossible. This guide, written from more than a decade of andrological practice in Istanbul, explains the two phases of the disease, which non-surgical treatments actually work, and the exact clinical thresholds that push a urologist to recommend surgery.<\/p>\n<div class=\"dci-tldr\">\n<h2>Key takeaways<\/h2>\n<ul>\n<li>Peyronie&#8217;s has two phases: acute (painful, changing) and chronic (stable curvature).<\/li>\n<li>Spontaneous resolution is rare \u2014 around 12\u201313%; roughly half of men worsen without treatment.<\/li>\n<li>Non-surgical options work best in the acute phase: traction devices (Penimaster \/ RestoreX, 30 min\/day), verapamil injections, oral pentoxifylline, and \u2014 in the United States only \u2014 Xiaflex (collagenase).<\/li>\n<li>Surgery is offered when disease is stable &gt;12 months, curvature &gt;30\u00b0, or intercourse is impossible. Plication for shorter penises with simple curves, grafting for complex or hourglass deformities, and a penile prosthesis when <a href=\"\/de\/treatments_urology\/erectile-dysfunction\/\">erectile dysfunction<\/a> coexists.<\/li>\n<li>Modern surgical outcomes: straightening in 85\u201395% of cases, satisfaction &gt; 80%.<\/li>\n<\/ul>\n<\/div>\n<nav class=\"dci-toc\" aria-label=\"Article contents\">\n<p class=\"dci-toc-title\">Table of contents<\/p>\n<ol>\n<li><a href=\"#what-is-peyronies\">What is Peyronie&#8217;s disease?<\/a><\/li>\n<li><a href=\"#phases\">The two phases: acute vs chronic<\/a><\/li>\n<li><a href=\"#does-it-heal\">Does Peyronie&#8217;s ever heal by itself?<\/a><\/li>\n<li><a href=\"#watchful-waiting\">Watchful waiting \u2014 who and when<\/a><\/li>\n<li><a href=\"#oral-therapy\">Oral therapy: what actually works<\/a><\/li>\n<li><a href=\"#traction\">Traction devices (RestoreX, Penimaster)<\/a><\/li>\n<li><a href=\"#injections\">Intralesional injections: Xiaflex &amp; verapamil<\/a><\/li>\n<li><a href=\"#shockwave\">Shockwave therapy for Peyronie&#8217;s<\/a><\/li>\n<li><a href=\"#surgery-plication\">Surgery 1 \u2014 Plication (Nesbit, 16-dot)<\/a><\/li>\n<li><a href=\"#surgery-grafting\">Surgery 2 \u2014 Plaque incision &amp; grafting<\/a><\/li>\n<li><a href=\"#surgery-implant\">Surgery 3 \u2014 Penile prosthesis with straightening<\/a><\/li>\n<li><a href=\"#recovery\">Recovery and outcome expectations<\/a><\/li>\n<li><a href=\"#doctors-perspective\">Doctor&#8217;s perspective \u2014 Op. Dr. Cem \u0130pek<\/a><\/li>\n<li><a href=\"#when-to-see\">When to see a urologist<\/a><\/li>\n<li><a href=\"#faq\">Frequently asked questions<\/a><\/li>\n<\/ol>\n<\/nav>\n<h2 id=\"what-is-peyronies\">What is Peyronie&#8217;s disease?<\/h2>\n<p><strong>Peyronie&#8217;s disease<\/strong> is the formation of fibrous scar tissue \u2014 called plaque \u2014 inside the <em>tunica albuginea<\/em>, the thick sheath surrounding the erectile chambers of the penis. When the penis fills with blood, the scarred segment cannot stretch as much as the healthy tissue around it. The result is curvature, indentation, hourglass narrowing, or shortening.<\/p>\n<p>Anatomical length or girth is a separate procedure \u2014 details on our <a href=\"\/de\/penis-enlargement-surgery\/\">penis enlargement surgery<\/a> page.<\/p>\n<p>The most widely accepted trigger is repeated micro-trauma during intercourse in a genetically susceptible man. Risk factors include Dupuytren&#8217;s contracture of the hand, connective tissue disorders, diabetes, low testosterone, previous prostate surgery, and family history.<\/p>\n<h2 id=\"phases\">The two phases: acute vs chronic<\/h2>\n<p>Understanding which phase you are in is the single most important step, because it changes every treatment decision.<\/p>\n<p>An office-based option worth mentioning is <a href=\"\/de\/glans-penis-head-filler-in-the-treatment-of-premature-ejaculation-op-dr-cem-ipek\/\">glans (penis head) filler for premature ejaculation<\/a>.<\/p>\n<table>\n<thead>\n<tr>\n<th>Feature<\/th>\n<th>Acute (inflammatory) phase<\/th>\n<th>Chronic (stable) phase<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Duration<\/td>\n<td>0\u201312 months typically<\/td>\n<td>After 12+ months of no change<\/td>\n<\/tr>\n<tr>\n<td>Pain with erection<\/td>\n<td>Yes, often<\/td>\n<td>Rare<\/td>\n<\/tr>\n<tr>\n<td>Curvature<\/td>\n<td>Changing (may worsen or improve)<\/td>\n<td>Fixed<\/td>\n<\/tr>\n<tr>\n<td>Plaque<\/td>\n<td>Soft, tender<\/td>\n<td>Firm, sometimes calcified<\/td>\n<\/tr>\n<tr>\n<td>Best treatments<\/td>\n<td>Oral, traction, injection<\/td>\n<td>Surgery if functionally significant<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Operating during the acute phase is a mistake \u2014 the deformity is still evolving, and any correction may be undone as the disease continues. Waiting for stability is not procrastination; it is the standard of care.<\/p>\n<h2 id=\"does-it-heal\">Does Peyronie&#8217;s disease heal by itself?<\/h2>\n<p>The honest data:<\/p>\n<ul>\n<li>Spontaneous <strong>improvement<\/strong> in curvature: about <strong>12\u201313%<\/strong> of untreated men<\/li>\n<li>No change: about 40%<\/li>\n<li><strong>Worsening<\/strong>: about 40\u201350%<\/li>\n<\/ul>\n<p>Pain almost always resolves within 12\u201318 months on its own, but that is not the same as the disease resolving \u2014 the curvature usually remains and often progresses. &#8220;Wait and see&#8221; without any active management is only appropriate for men with minimal curvature (&lt;20\u00b0), no pain, and preserved sexual function.<\/p>\n<h2 id=\"watchful-waiting\">Watchful waiting \u2014 who and when<\/h2>\n<p>Reasonable candidates for observation alone:<\/p>\n<p>A nerve-targeted alternative when medication fails is <a href=\"\/de\/selective-dorsal-cryoablation-for-premature-ejaculation\/\">selective dorsal cryoablation for premature ejaculation<\/a>.<\/p>\n<ul>\n<li>Curvature under 20 degrees<\/li>\n<li>No pain or pain fading month over month<\/li>\n<li>Intercourse still possible without difficulty for both partners<\/li>\n<li>No hourglass deformity or hinge effect<\/li>\n<li>Willing to return every three months for photographic reassessment<\/li>\n<\/ul>\n<p>Even these men benefit from starting a low-risk traction protocol early \u2014 because the tissue is more responsive during the acute phase.<\/p>\n<h2 id=\"oral-therapy\">Oral therapy: what actually works<\/h2>\n<p>Oral treatments have modest and often disappointing effects, but a few are used because side effects are low and the acute-phase window is limited:<\/p>\n<p>For an honest breakdown of what enlargement really delivers, see the <a href=\"\/de\/penis-enlargement-truth\/\">penis enlargement truth<\/a>.<\/p>\n<ul>\n<li><strong>Pentoxifylline 400 mg \u00d7 3\/day<\/strong> \u2014 anti-fibrotic; the best oral evidence, particularly for early plaques<\/li>\n<li><strong>Vitamin E 400 IU\/day<\/strong> \u2014 mixed evidence; largely obsolete as monotherapy, still used as adjunct<\/li>\n<li><strong>L-carnitine, coenzyme Q10, colchicine<\/strong> \u2014 weak evidence; not recommended by EAU as monotherapy<\/li>\n<li><strong>Tadalafil 5 mg daily<\/strong> \u2014 reduces smooth-muscle fibrosis and treats any coexisting ED (roughly 50% of Peyronie&#8217;s patients)<\/li>\n<\/ul>\n<p>No oral drug has been shown to reliably reduce established curvature. Use them as part of a combined protocol, not a standalone cure.<\/p>\n<h2 id=\"traction\">Traction devices (RestoreX, Penimaster)<\/h2>\n<p>Mechanical traction is one of the few conservative treatments with genuine evidence of reducing curvature \u2014 but only if used properly.<\/p>\n<ul>\n<li><strong>RestoreX<\/strong> (US-developed, Mayo Clinic trial data): 30\u201390 minutes daily; average curvature reduction 10\u201317 degrees, length gain 1.5 cm over 3 months<\/li>\n<li><strong>Penimaster PRO<\/strong> (European): similar mechanism, comparable results with 4\u20138 hours daily use<\/li>\n<li><strong>Andropenis<\/strong>: older design, still useful, tolerability lower<\/li>\n<\/ul>\n<p>Traction works because collagen remodels under sustained tension. It works best in the acute phase and as an adjunct to injections. Compliance is the enemy \u2014 most men who fail traction did not use the device long enough.<\/p>\n<h2 id=\"injections\">Intralesional injections: Xiaflex &amp; verapamil<\/h2>\n<p><strong>Collagenase Clostridium histolyticum (Xiaflex)<\/strong> is the only FDA-approved non-surgical therapy for Peyronie&#8217;s. It enzymatically breaks down the collagen in the plaque. Standard protocol: 4 cycles, each with 2 injections plus modeling. Average curvature reduction: <strong>34% (about 17 degrees)<\/strong>.<\/p>\n<p>For international pricing, read <a href=\"\/de\/penile-implant-cost-turkey\/\">penile implant cost in Turkey<\/a>.<\/p>\n<p><strong>Important:<\/strong> Xiaflex is licensed in the United States. It is <strong>not available in Turkey<\/strong>, and it was withdrawn from the European market in 2020. International patients seeking Xiaflex must travel to the US.<\/p>\n<p><strong>Verapamil intralesional injection<\/strong> is our workhorse alternative in Turkey and much of Europe. Ten milligrams diluted, injected directly into the plaque every two weeks for 12 sessions. Evidence quality is lower than Xiaflex, but properly delivered verapamil reduces curvature in roughly 50\u201360% of men, with a good safety profile and low cost.<\/p>\n<p><strong>Interferon-alpha-2b<\/strong> is another option with mid-level evidence, more inflammation post-injection, and higher cost. Rarely first-line in our clinic.<\/p>\n<div class=\"dci-cta\">\n<p>Not sure whether you are in the acute or chronic phase \u2014 or which treatment is right for you?<\/p>\n<p><a href=\"\/de\/contact\/\">Book a Peyronie&#8217;s disease assessment with Dr. Cem \u0130pek \u2192<\/a><\/p>\n<\/div>\n<h2 id=\"shockwave\">Shockwave therapy for Peyronie&#8217;s<\/h2>\n<p>Low-intensity extracorporeal <a href=\"\/de\/shockwave-therapy-for-erectile-dysfunction\/\">shockwave therapy<\/a> (LI-ESWT) is very useful for erectile dysfunction, but for Peyronie&#8217;s the evidence is much more limited. Current consensus (EAU 2024): shockwave reliably reduces pain in the acute phase but does <strong>not<\/strong> significantly straighten established curvature. We use it for painful acute disease as an adjunct, not as a standalone straightening treatment.<\/p>\n<h2 id=\"surgery-plication\">Surgery 1 \u2014 Plication (Nesbit &amp; 16-dot)<\/h2>\n<p>Plication techniques shorten the side of the penis opposite the curve to straighten the shaft. The classic <strong>Nesbit procedure<\/strong> removes a small wedge of tunica; the modern <strong>16-dot (Lue) technique<\/strong> uses non-absorbable sutures without tissue excision, preserving anatomy and length as much as possible.<\/p>\n<p>A device-by-device breakdown is in our <a href=\"\/de\/inflatable-vs-malleable-penile-implant\/\">inflatable vs malleable penile implant guide<\/a>.<\/p>\n<p><strong>Best candidate:<\/strong><\/p>\n<ul>\n<li>Curvature under 60 degrees<\/li>\n<li>No hourglass or hinge deformity<\/li>\n<li>Adequate penile length (plication shortens by 0.5\u20131.5 cm)<\/li>\n<li>Good baseline erections<\/li>\n<\/ul>\n<p>Straightening success: 85\u201395%. Recurrence: 5\u201310%. Palpable sutures possible but rarely troublesome. Return to sex: 6 weeks.<\/p>\n<h2 id=\"surgery-grafting\">Surgery 2 \u2014 Plaque incision &amp; grafting<\/h2>\n<p>For severe curvature (&gt;60\u00b0), hourglass narrowing, or short penises where plication would shorten too much, the surgeon incises the plaque and patches the defect with a graft \u2014 usually bovine pericardium (Tutoplast), porcine small intestinal submucosa, or occasionally the patient&#8217;s own tissue.<\/p>\n<p>Evidence-based, non-drug techniques are in our guide on <a href=\"\/de\/how-to-last-longer-in-bed\/\">how to last longer in bed<\/a>.<\/p>\n<p>Grafting preserves length and corrects complex deformity but carries a higher risk of postoperative ED (10\u201320%) because the surgery is closer to the neurovascular bundle. Careful patient selection \u2014 and thorough preoperative evaluation of erectile function including penile Doppler ultrasound \u2014 is essential.<\/p>\n<h2 id=\"surgery-implant\">Surgery 3 \u2014 Penile prosthesis with straightening<\/h2>\n<p>When Peyronie&#8217;s coexists with significant erectile dysfunction that does not respond to PDE5 inhibitors, the best single operation is a <a href=\"\/de\/treatments_urology\/penile-prosthesis-surgery\/\">penile prosthesis (implant)<\/a> combined with intraoperative straightening \u2014 usually manual modeling, or if needed, plication or a small graft during the same procedure.<\/p>\n<p>This solves two problems in one operation:<\/p>\n<ul>\n<li>Reliable erection on demand<\/li>\n<li>Straight, functional penis<\/li>\n<\/ul>\n<p>Modern three-piece inflatable prostheses have satisfaction rates above 90% in Peyronie&#8217;s patients \u2014 often higher than in the general ED population, because these men have suffered longer.<\/p>\n<h2 id=\"recovery\">Recovery and outcome expectations<\/h2>\n<table>\n<thead>\n<tr>\n<th>Milestone<\/th>\n<th>Plication<\/th>\n<th>Grafting<\/th>\n<th>Implant + straightening<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Hospital stay<\/td>\n<td>Day case<\/td>\n<td>1 night<\/td>\n<td>1 night<\/td>\n<\/tr>\n<tr>\n<td>Back to office work<\/td>\n<td>3\u20135 days<\/td>\n<td>7 days<\/td>\n<td>7 days<\/td>\n<\/tr>\n<tr>\n<td>Return to intercourse<\/td>\n<td>6 weeks<\/td>\n<td>6\u20138 weeks<\/td>\n<td>4\u20136 weeks<\/td>\n<\/tr>\n<tr>\n<td>Straightening success<\/td>\n<td>85\u201395%<\/td>\n<td>80\u201390%<\/td>\n<td>90\u201395%<\/td>\n<\/tr>\n<tr>\n<td>ED risk from surgery<\/td>\n<td>&lt;5%<\/td>\n<td>10\u201320%<\/td>\n<td>N\/A (implant restores)<\/td>\n<\/tr>\n<tr>\n<td>Sensation change<\/td>\n<td>Rare<\/td>\n<td>Occasional<\/td>\n<td>Occasional<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Nighttime traction with a RestoreX or Penimaster is often continued for 6\u201312 weeks after any Peyronie&#8217;s surgery to counteract postoperative scar contracture.<\/p>\n<p>A complete comparison of sprays, pills, injections and surgery is in our <a href=\"\/de\/premature-ejaculation-treatment\/\">premature ejaculation treatment<\/a> guide.<\/p>\n<h2 id=\"doctors-perspective\">Doctor&#8217;s perspective \u2014 Op. Dr. Cem \u0130pek<\/h2>\n<blockquote><p>The men who do worst are those who wait five years hoping the curve will go away. By the time they come to see me, the plaque is calcified, ED has taken hold, and half the reconstructive options are already off the table. Come in during the first year, even if all we do is start a traction protocol \u2014 the tissue is still plastic then.<\/p><\/blockquote>\n<blockquote><p>Xiaflex works, but the noise around it in the English-speaking internet is out of proportion. In real numbers it reduces curvature by about a third \u2014 meaningful, but rarely enough for a 70-degree bend. Verapamil injection plus disciplined traction, done for the full 12-week protocol, gives outcomes very close to Xiaflex at a fraction of the cost, and it is available across Europe.<\/p><\/blockquote>\n<blockquote><p>When curvature has been stable for a year and intercourse is impossible, surgery is not a luxury \u2014 it is the treatment. Modern plication for a simple 45-degree curve is a one-hour outpatient procedure with a return to sex in six weeks and a satisfaction rate above 90%. Delaying it does not preserve options; it narrows them.<\/p><\/blockquote>\n<h2 id=\"when-to-see\">When to see a urologist<\/h2>\n<p>Book an appointment if any of the following applies:<\/p>\n<ul>\n<li>Painful erection lasting more than four weeks<\/li>\n<li>A palpable lump or nodule under the penile skin<\/li>\n<li>New or worsening curvature, hourglass, or indentation<\/li>\n<li>Penis feels shorter than before<\/li>\n<li>Intercourse has become difficult or painful for either partner<\/li>\n<li>New erectile dysfunction alongside any of the above<\/li>\n<li>Family or personal history of Dupuytren&#8217;s contracture<\/li>\n<\/ul>\n<p>Early evaluation almost always widens your treatment options \u2014 and lowers the chance that surgery will be the only remaining choice.<\/p>\n<div class=\"dci-cta\">\n<p><strong>Ready for a full Peyronie&#8217;s assessment?<\/strong><\/p>\n<p>Andrological consultation with penile Doppler ultrasound, photographic curvature measurement, and a written treatment plan at Androaesthe Istanbul.<\/p>\n<p><a href=\"\/de\/contact\/\">Request an international patient consultation \u2192<\/a> \u00b7 <a href=\"\/de\/treatments_urology\/peyronies-disease\/\">Learn about our Peyronie&#8217;s programme \u2192<\/a><\/p>\n<\/div>\n<h2 id=\"faq\">Frequently asked questions<\/h2>\n<div class=\"dci-faq\">\n<details>\n<summary>Can Peyronie&#8217;s disease be cured?<\/summary>\n<p>Peyronie&#8217;s cannot be cured in the strict sense \u2014 the plaque itself rarely disappears. But curvature can be reduced or fully corrected with appropriate treatment, and normal sexual function can be restored in the majority of patients. In practical terms, &#8220;cured&#8221; means a straight, functional penis with satisfying intercourse, which is achievable for most men.<\/p>\n<\/details>\n<details>\n<summary>How long does Peyronie&#8217;s disease last?<\/summary>\n<p>The acute (inflammatory) phase typically lasts 6\u201318 months. After that, the disease enters a stable chronic phase. Without treatment, the curvature usually persists lifelong. Pain resolves in most men within 18 months regardless of treatment.<\/p>\n<\/details>\n<details>\n<summary>Is Xiaflex worth it?<\/summary>\n<p>Xiaflex is the only FDA-approved non-surgical option and reduces curvature by about 34% on average. It is expensive, requires four treatment cycles, and is only available in the United States (withdrawn from Europe in 2020). Worth it if you have moderate curvature (30\u201360\u00b0), no calcification, and access to a US provider \u2014 otherwise verapamil injection plus traction is a strong alternative.<\/p>\n<\/details>\n<details>\n<summary>When is Peyronie&#8217;s surgery necessary?<\/summary>\n<p>Surgery is offered when three conditions are met: the disease has been stable for at least 12 months, curvature exceeds 30 degrees (or there is significant hourglass\/hinge deformity), and intercourse is impaired. Type of surgery \u2014 plication, grafting, or implant \u2014 depends on the severity, penile length, and presence of erectile dysfunction.<\/p>\n<\/details>\n<details>\n<summary>Will my penis be shorter after surgery?<\/summary>\n<p>Plication techniques shorten the erect penis by 0.5\u20131.5 cm on average. Grafting techniques are length-preserving. Penile prosthesis with straightening can even restore some perceived length that was lost to the disease. Nighttime traction after surgery helps minimise shortening.<\/p>\n<\/details>\n<details>\n<summary>Does insurance cover Peyronie&#8217;s treatment?<\/summary>\n<p>In most countries, medically necessary Peyronie&#8217;s surgery is covered by public or private insurance when curvature prevents intercourse. Cosmetic-only correction is usually not covered. In Turkey, international self-pay patients pay a single all-inclusive package price at private andrology centres.<\/p>\n<\/details>\n<details>\n<summary>Can Peyronie&#8217;s come back after surgery?<\/summary>\n<p>Recurrence of significant curvature after plication is 5\u201310%, mostly because the underlying disease process can produce new plaques. Grafting has similar rates. Recurrence is minimised by operating only after 12 months of stability, and by using postoperative traction for 6\u201312 weeks.<\/p>\n<\/details>\n<\/div>\n<div class=\"dci-author\">\n<div class=\"dci-author-photo\" aria-hidden=\"true\"><\/div>\n<div class=\"dci-author-text\">\n<p class=\"dci-author-name\">Op. Dr. Cem \u0130pek, MD<\/p>\n<p>Board-certified urologist and andrologist based in Istanbul, specialising in Peyronie&#8217;s disease reconstruction, penile prosthesis surgery, erectile dysfunction, and male genital aesthetic surgery. Treats patients from more than 20 countries at Androaesthe Clinic.<\/p>\n<p><a href=\"\/de\/about-us\/\">About Dr. Cem \u0130pek \u2192<\/a> \u00b7 <a href=\"\/de\/contact\/\">Book consultation \u2192<\/a><\/p>\n<\/div>\n<\/div>\n<div class=\"dci-refs\">\n<strong>References<\/strong><\/p>\n<ol>\n<li>European Association of Urology (EAU) Guidelines on Sexual and Reproductive Health \u2014 Peyronie&#8217;s Disease, 2024 edition.<\/li>\n<li>American Urological Association (AUA) Guideline: Peyronie&#8217;s Disease, 2015 (amended 2023).<\/li>\n<li>Gelbard M et al. <em>Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for Peyronie&#8217;s disease (IMPRESS I and II trials).<\/em> J Urol. PMID: 23916535.<\/li>\n<li>Ziegelmann MJ et al. <em>Restoration of Penile Function and Patient Satisfaction with Intralesional Collagenase Injection.<\/em> J Sex Med. PMID: 27235020.<\/li>\n<li>Kad\u0131o\u011flu A et al. <em>Peyronie&#8217;s disease: contemporary review of the treatment options.<\/em> Turk J Urol. PMID: 30875299.<\/li>\n<li>Alom M et al. <em>Efficacy of combined collagenase clostridium histolyticum and RestoreX penile traction therapy in men with Peyronie&#8217;s disease.<\/em> J Sex Med. PMID: 31255205.<\/li>\n<\/ol>\n<\/div>\n<\/article>\n<p><script type=\"application\/ld+json\">\n{\n  \"@context\": \"https:\/\/schema.org\",\n  \"@graph\": [\n    {\n      \"@type\": \"MedicalWebPage\",\n      \"@id\": \"https:\/\/drcemipek.com\/peyronies-disease-treatment\/#webpage\",\n      \"url\": \"https:\/\/drcemipek.com\/peyronies-disease-treatment\/\",\n      \"name\": \"Peyronie's Disease Treatment: Curvature, Xiaflex & Surgery\",\n      \"description\": \"Peyronie's disease rarely resolves on its own. 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